Almost half of of patients have reversed type 2 diabetes in a "watershed" trial, say medical doctors in newcastle and glasgow.
Human beings spent up to five months on a low-calorie food regimen of soups and shakes to trigger big weight loss.
Isobel murray, sixty five, who had weighed 15 stone, lost over four stone (25kg) and no longer wishes diabetes pills. She says: "i've got my life lower back."
The charity diabetes united kingdom says the trial is a landmark and has the potential to assist hundreds of thousands of sufferers.
Isobel, from largs in north ayrshire, changed into considered one of 298 people on the trial.
Her blood sugar degrees have been too high, and each time she went to the doctors they elevated her medication.
So, she went directly to the all-liquid food plan for 17 weeks - giving up cooking and buying. She even ate aside from her husband, jim.
Alternatively, she had four liquid meals a day.
It's far infrequently masterchef - a sachet of powder is stirred in water to make a soup or shake. They comprise approximately 2 hundred calories, however additionally the proper stability of vitamins.
Isobel advised the bbc it become particularly easy as "you don't should think about what you consume".
As soon as the load has been lost, dieticians then assist sufferers introduce wholesome, strong food.
"consuming everyday meals is the toughest bit," says isobel.
The trial outcomes, concurrently posted within the lancet medical journal and provided at the global diabetes federation, showed:
46% of patients who started the trial have been in remission a yr later
86% who misplaced 15kg (2st 5lb) or extra put their kind 2 diabetes into remission
Most effective 4% went into remission with the fine remedies presently used
Prof roy taylor, from newcastle university, told the bbc: "it's a real watershed moment.
"earlier than we started this line of work, medical doctors and professionals regarded type 2 as irreversible.
"however if we draw close the nettle and get humans out of their dangerous nation, they can get remission of diabetes."
However, medical doctors aren't calling this a treatment. If the weight is going returned on, then the diabetes will go back.
"i can in no way pass there once more," says isobel. Thus far, she has kept the load off for two years.
Why does losing weight work?
Frame fats building up around the pancreas reasons strain to the beta cells inside the organ that controls blood sugar stages.
They stop producing enough of the hormone insulin, and that reasons blood sugar stages to rise out of manipulate.
Dieting loses the fat, and then the pancreas works nicely once more.
The trial looked at most effective patients recognized inside the beyond six years. It is concept having kind 2 diabetes for terribly lengthy intervals of time may cause irreversible damage.
Prof mike lean, from glasgow university, instructed the bbc: "it is extremely interesting."
"we now have clear proof that weight loss of 10-15kg is enough to show this ailment round.
One in 11 adults global has diabetes, and maximum of them have type 2.
Out of control sugar degrees motive damage at some point of the frame, leading to organ failure, blindness and limb amputations.
Treating the disorder charges the United Kingdom's nhs about £10bn a yr.
Dr elizabeth robertson, the director of studies at diabetes uk, said: "[The trial has] the ability to convert the lives of tens of millions of humans.
"the trial is ongoing, in order that we are able to understand the lengthy-term results of an technique like this."
Isobel stated: "i do not examine myself as a diabetic in any respect.
"you need to be fired up, you have to be prepared, but every person can do it if you sense strongly enough."
